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Sr. Systems Analyst - Bioinformatics

Req # 32312 Job Location Los Angeles, California - US
Give your career the best treatment.
Ready to be part of the first and largest pediatric hospital in Southern California? This is Children's Hospital Los Angeles. A place where you can make a real difference in the lives of our patients and their families. A big responsibility? Absolutely. But if you’re up for the challenge, we’re on the lookout for amazing professionals to join our elite teams – talented individuals who can continue our high level of care.

In collaboration with other scientists, clinicians and bioinformatics staff within the Center for Personalized Medicine, the Sr. Systems Analyst - Bioinformatics will lead development of new clinical pipelines, algorithms and visualization tools for clinical test application. Responsible for managing and working with large-scale next generation sequencing (NGS) data such as Whole Genome, Whole Exome, RNA-seq and ChIP-Seq within a Linux/Unix environment on a high-performance computing cluster (SGE/PBS/Torque). Use existing bioinformatics tools for performing sequence alignment, variant calling, copy number detection, variant annotation, etc. Integrating various private and publicly available genomic annotations from databases such as ExAC, ClinVar, TCGA, OMIM, NCBI, UCSC, Ensembl, HGMD, etc. Work on integrating a Laboratory Information Management System (LIMS) with the existing workflows and also assist with the development of new workflows. Use scripting languages such as R or Python and carry out database development using MySQL/MongoDB. Use software version tracking systems such as Git for code development. Provide direction, planning and application development to staff and leadership in support of the center's clinical requirements, computational and analytical needs, and related websites in concordance with best practices. Leads and mentors junior staff. Works directly with Scientists and laboratory staff to design, plan and execute validation plans for implementation of laboratory developed tests (LDTs). Suggests and implements solutions that comply with hospital guidelines and meets the requirements for security, supportability and portability while maintaining compliance with regulatory bodies. Implement state-of-the art computational methods, and develop innovative methods toward the development of rigorous diagnostic tests. Functions both independently and in a team. Write SOPs and train users. Interact with clients, vendors, scientists, and hospital IT Support group.

Minimum Education: Master’s degree in Bioinformatics

Minimum Experience: 1 year experience or 1 year related experience
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